My own experience of Lyme Bay is limited to fairly benign conditions, and on a yot, at that
I don't think there's anything particularly de trop about the weather in Lyme Bay - when it's horrible, it's as nasty as anywhere else that has no immediate shelter. The problem is more that there's no real port of refuge, particularly if the wind is onshore. West Bay (Bridport) has what looks like a nightmareish entrance between two lengthy breakwaters and, though I've only seen Lyme Regis from ashore, I don't think I'd like to try getting through the entrance in any kind of a sea. Plus both are tidal (I think? Certainly Lyme is).
It's a psychological problem as much as anything. If you go straight across, you're out of sight of land for quite a long time and quite a long way from shelter. If you hug the coast, at least you can see land, but you're still miles from shelter and it may make for quite an uncomfortable feeling if the weather is tending to push you towards terra firma .
I seem to recall that Robin Knox-Johnson was navigator for Shelley Jory a couple of years ago, in the Cowes-Torquay-Cowes race and he opted to go inshore, in quite rough conditions. They fared rather better, and were quicker, than people who went offshore.
Purely imho. Someone who really knows what they're talking about will be along in a minute.
Itis apis spotanda bigon etoo